b-AP15 (NSC-687852), DUB inhibitor (TBI1340)
$99.00 – $387.00
DUB inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1340-5MG | Yes | 5 MG | $99.00 | |||
TBI1340-25MG | Yes | 25 MG | $387.00 |
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Description
Product Details
Formal Name: 3,5-bis[(4-Nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one
Alternate Names: NSC-687852
Molecular Formula: C22H17N3O6
Formula Weight: 419.40
CAS Number: 1009817-63-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
DUB inhibitor
Functions
Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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