AZ3146, Msp1 kinase inhibitor (TBI4778)
$108.00 – $351.00
Msp1 kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4778-5MG | Yes | 5 MG | $108.00 | |||
TBI4778-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: 9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-one
Molecular Formula: C24H32N6O3S2
Formula Weight: 452.56
CAS Number: 1124329-14-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Msp1 kinase inhibitor
Functions
AZ3146 is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor. Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).
Application Procedures
First dissolved in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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