AT-101, Bcl-2 inhibitor (TBI1165)

Description

Product Details

Alternate Names: Gossypol R(-)

Molecular Formula: C₃₀H₃₀O₈

Formula Weight: 518.56

CAS Number: 90141-22-3

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

Bcl-2 inhibitor

 

Functions

A small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. Induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.

 

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

 

Additional information

SIZE (mg)	10 MG, 50 MG

TBI1165_AT-101