AS-1949490, SHIP2 inhibitor (TBI5103)
$112.00 – $446.00
SHIP2 inhibitor
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI5103-5MG | Yes | 5 MG | $112.00 | |||
| TBI5103-25MG | Yes | 25 MG | $446.00 |
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Description
Product Details
Formal Name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]-2-thiophenecarboxamide
Molecular Formula: C20H18ClNO2S
Formula Weight: 371.90
CAS Number: 1203680-76-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 40 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
SHIP2 inhibitor
Functions
A potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5′-phosphatase 2), IC50 = 0.62 µM. Displays ca. 30-fold selectivity for SHIP2 over SHIP. Activates insulin signaling via the Akt pathway in liver and lowers glucose levels in diabetic mice. Enhances BDNF expression in cultured cortical neurons. Ameliorates ROS generation but aggravates apoptosis in CD2AP-deficient mouse podocytes.
Application Procedures
First dissolved in DMSO (up to at least 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
| SIZE (mg) | 25 MG, 5 MG |
|---|
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