Apilimod, IL12/23 inhibitor/Inhibits SARS-CoV2 infection (TBI4970)
$81.00 – $288.00
IL12/23 inhibitor/Inhibits SARS-CoV2 infection
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4970-5MG | Yes | 5 MG | $81.00 | |||
TBI4970-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Formal Name: N-[(E)-(3-Methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
Alternate Names: STA-5326
Molecular Formula: C23H26N6O2
Formula Weight: 418.50
CAS Number: 541550-19-0
Purity: >99%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
IL12/23 inhibitor/Inhibits SARS-CoV2 infection
Functions
Potent and selective inhibitor of the TLR signaling lipid kinase PIKfyve (IC50 = 14 nM), but not other lipid or protein kinases. Blocks transcription of IL-12 p35 and IL-12/IL-23 p40 genes via transcriptional repressor ATF32, leading to suppression of Th1, but not Th2, immune response. Cytotoxic against B-cell non-Hodgkin lymphoma in vivo, and reduces PtdIns5P and PtdIns(3,5)P2 levels in transformed and immortalized cell lines. Blocks SARS-CoV-2 infection in vitro, likely via reduction in cathepsin protease activation.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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