AP-18, TRPA1 blocker (TBI1127)
$117.00 – $468.00
TRPA1 blocker
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1127-10MG | Yes | 10 MG | $117.00 | |||
TBI1127-50MG | Yes | 50 MG | $468.00 |
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Description
Product Details
Formal Name: 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Molecular Formula: C11H12ClNO
Formula Weight: 209.67
CAS Number: 55224-94-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
TRPA1 blocker
Functions
TRPA1 channel blocker IC50=3.1-4.5 µM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 µM. Blocks TRPA1 pore dilation (IC50=10.3 µM). An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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