Anacardic Acid, HAT Inhibitor (TBI4015)
$63.00 – $252.00
HAT Inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4015-5MG | Yes | 5 MG | $63.00 | |||
TBI4015-25MG | Yes | 25 MG | $252.00 |
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Description
Product Details
Formal Name: 2-Hydroxy-6-pentadecylbenzoic acid
Alternate Names: 6-Pentadecylsalicylic acid; 6-PDSA
Molecular Formula: C22H36O3
Formula Weight: 348.50
CAS Number: 16611-84-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (15 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
HAT Inhibitor
Functions
Anacardic acids occur in cashew nut shells and are similar in structure to urushiols, the irritating components of poison ivy. Anacardic acid inhibits histone acetyltransferases (HATs) p300 (IC50 = 8.5 µM) and PCAF (IC50 = 5.0 µM) with no effect on HDACs. It also suppresses expression or activity of proteins involved in invasion and angiogenesis, e.g. MMP-2 (IC50 = 11 µM) and -92. 6-PDSA, a saturated form of anacardic acid, induces macrophage activation via MAPK and NF-κB3. When used at 125 µM, it sensitized cancer cells to radiation therapy by reducing histone expression. It also blocks inducible and constitutive activation of NF-κB in leukemia cells.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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