AK-7, SIRT2 inhibitor (TBI1429)
$99.00 – $396.00
SIRT2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1429-5MG | Yes | 5 MG | $99.00 | |||
TBI1429-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 3-(1-Azepanylsulfonyl)-N-(3-bromophenyl)benzamide
Molecular Formula: C19H21BrN2O3S
Formula Weight: 437.36
CAS Number: 420831-40-9
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
Storage: RT
Stability: ≥ 2 years.
Applications
- SIRT2 inhibitor
Functions
AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3. It down regulates cholesterol biosynthesis genes in primary striatal neurons. AK-7 displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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