Adavosertib (MK-1775), Wee1 checkpoint kinase inhibitor (TBI5462)
$81.00 – $279.00
Wee1 checkpoint kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI5462-5MG | Yes | 5 MG | $81.00 | |||
TBI5462-25MG | Yes | 25 MG | $279.00 |
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Description
Product Details
Formal Name: 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)-phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
Alternate Names: MK-1775; AZD 1775
Molecular Formula: C27H32N8O2
Formula Weight: 500.60
CAS Number: 955365-80-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (70 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Wee1 checkpoint kinase inhibitor
Functions
Inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage checkpoint, sensitizing a variety of tumor cells to DNA damaging agents. Adavosertib also blocks Wee1 phosphorylation of E3 ubiquitin ligase SKP2 in human cells, ultimately preventing degradation of CDKs and further allowing cell cycle progression. Stimulates anti-tumor immunity and enhances sensitivity to immune checkpoint blockade by activating ERV and the dsRNA pathway. Potentiates sensitivity of tumors to PARP inhibitors.
Application Procedures
First dissolved in DMSO (70 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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