Acalabrutinib, Highly selective BTK inhibitor (TBI4806)
$81.00 – $261.00
Highly selective BTK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4806-5MG | Yes | 5 MG | $81.00 | |||
TBI4806-25MG | Yes | 25 MG | $261.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide
Alternate Names: ACP-196
Molecular Formula: C26H23N7O2
Formula Weight: 465.52
CAS Number: 1420477-60-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Highly selective BTK inhibitor
Functions
Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK). Improved target selectivity (especially against TEC family kinases and EGFR) decreased the number of serious side effects observed with Ibrutinib. Acalabrutinib significantly inhibits BCR signaling, inhibits tumor proliferation, and reduces tumor burden. Clinically useful agent for treating B-cell cancers. BTK has also been shown to have a role in modulating the innate immune system, especially in dendritic cells and macrophages, suggesting a possible role in immunotherapy.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “Acalabrutinib, Highly selective BTK inhibitor (TBI4806)”
You must be logged in to post a review.
Reviews
There are no reviews yet.