Abemaciclib, CDK 4/6 inhibitor (TBI4833)
$90.00 – $207.00
CDK 4/6 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4833-5MG | Yes | 5 MG | $90.00 | |||
TBI4833-25MG | Yes | 25 MG | $207.00 |
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Description
Product Details
Formal Name: N-[5-[(4-Ethylpiperazin-1-yl)methyl]pyridine-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine methanesulfonic acid salt
Alternate Names: LY2835219 mesylate
Molecular Formula: C27H32F2N8·CH3SO3H
Formula Weight: 602.70
CAS Number: 1231930-82-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
CDK 4/6 inhibitor
Functions
Potent and selective CDK4/6 inhibitor (IC50 = 2 nM and 10 nM respectively). Induces G1 cell cycle arrest in colo-205 colorectal cells, MDA-MB-361 breast cancer cells, and MV4-11 AML cells; also active in several human tumor xenograft models. Displays efficacy in patients with various solid tumors including breast cancer, non-small cell lung cancer, glioblastoma, melanoma, colorectal cancer, and hormone receptor-positive breast cancer. Abemaciclib induced a T cell inflamed tumor microenvironment and enhanced the efficacy of PD-L1 checkpoint blockade in MCF-7 breast cancer cells. FDA approved for the treatment of advanced breast cancers.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Water (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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