A83-01, ALK inhibitor (TBI1327)
$90.00 – $324.00
ALK inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1327-5MG | Yes | 5 MG | $90.00 | |||
TBI1327-25MG | Yes | 25 MG | $324.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Molecular Formula: C25H19N5S
Formula Weight: 421.50
CAS Number: 909910-43-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
ALK inhibitor
Functions
Potent and selective ALK4, 5 and 7 inhibitor. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts. Cell permeable. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “A83-01, ALK inhibitor (TBI1327)”
You must be logged in to post a review.
Reviews
There are no reviews yet.