A-196, Selective inhibitor of lysine methyltransferases SUV420H1/H2 (TBI4018)
$126.00 – $486.00
Selective inhibitor of lysine methyltransferases SUV420H1/H2
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI4018-5MG | Yes | 5 MG | $126.00 | |||
| TBI4018-25MG | Yes | 25 MG | $486.00 |
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Description
Product Details
Formal Name: Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine
Molecular Formula: C18H16Cl2N4
Formula Weight: 359.20
CAS Number: 1982372-88-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective inhibitor of lysine methyltransferases SUV420H1/H2
Functions
A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Additional information
| SIZE (mg) | 25 MG, 5 MG |
|---|
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