7-Cl-O-Nec1, RIPK1 inhibitor; Necroptosis inhibitor (TBI4544)
$108.00 – $369.00
RIPK1 inhibitor; Necroptosis inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4544-5MG | Yes | 5 MG | $108.00 | |||
TBI4544-25MG | Yes | 25 MG | $369.00 |
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Description
Product Details
Formal Name: 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione
Alternate Names: Nec-1s; Necrostatin1-S
Molecular Formula: C13H12ClN3O2
Formula Weight: 277.71
CAS Number: 852391-15-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
RIPK1 inhibitor; Necroptosis inhibitor
Functions
Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1. 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1). 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice. 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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