680C91, Tryptophan 2,3-dioxygenase inhibitor (TBI1443)
$122.00 – $490.00
Tryptophan 2,3-dioxygenase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1443-5MG | Yes | 5 MG | $122.00 | |||
TBI1443-25MG | Yes | 25 MG | $490.00 |
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Description
Product Details
Formal Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole
Molecular Formula: C15H11FN2
Formula Weight: 238.27
CAS Number: 163239-22-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Tryptophan 2,3-dioxygenase inhibitor
Functions
A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM). Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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