10074-G5, Myc inhibitor (TBI5627)
$99.00 – $306.00
Myc inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5627-5MG | Yes | 5 MG | $99.00 | |||
TBI5627-25MG | Yes | 25 MG | $306.00 |
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Description
Product Details
Formal Name: 7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
Molecular Formula: C18H12N4O3
Formula Weight: 332.30
CAS Number: 413611-93-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (40 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Myc inhibitor
Functions
Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity. 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 µM1. It was cytotoxic in c-Myc-overexpressing cell lines (IC50s = 13 to 15 µM) but was not active in vivo due to rapid metabolism. 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes. Binds to and sequesters the intrinsically disordered amyloid-β (Aβ) in its monomeric soluble state and rescues a C. elegans model of Aβ-associated toxicity.
Application Procedures
First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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