Alenphosome™ – Alendronate Liposomes (Neutral) (F70103A-N)
$437.00
SKU | Stock | SIZE (ml) | Price | Quantity | ||
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F70103A-N | Yes | 2 ML | $437.00 |
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Description
Alenphosome™ – Alendronate Liposomes (Neutral)
Specifications
Active: alendronate sodium (CAS 121268-17-5), 5.0 mg/mL
Volume: 2.0 mL
Lipid composition: phosphatidylcholine and cholesterol
Internal/External solution: phosphate buffered saline (20mM sodium phosphate, 09wt% NaCl), pH 7.0 – 7.5
Usage: warm to room temperature and mix well before use.
Dosage: this is a new product and no recommended dose is available at this point.
Additional information
SIZE (ml) | 2 ML |
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- Benjamin J. Burwitz et al. Technical Advance: Liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease. J Leukoc Biol. 2014 Sep; 96(3): 491–501. PMC4632165
- Renate Frei, Comparison of cytotoxic properties of free and liposomal bisphosphonates in vitro (Diploma Thesis) (Link)
- Mönkkönen J, van Rooijen N, Ylitalo P., Effects of clodronate and pamidronate on splenic and hepatic phagocytic cells of mice. Pharmacol Toxicol. 1991 Apr;68(4):284-6. (Link)
- Makkonen N, Hirvonen MR, Teräväinen T, Savolainen K, Mönkkönen J., Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro. J Pharmacol Exp Ther. 1996 May;277(2):1097-102 (link)
- van Rooijen N, Kors N. Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen. Calcif Tissue Int. 1989 Sep;45(3):153-6. (Link)
- Epstein H. et al., Preparation of alendronate liposomes for enhanced stability and bioactivity: in vitro and in vivo characterization. AAPS J. 2008 Dec;10(4):505-15. Epub 2008 Oct 21. (Link)
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