Aldometanib, Aldolase inhibitor (TBI4445)

Description

Product Details

Formal Name: 1-[(2,6-Dichlorophenyl)methyl]-3-hexadecyl-2-methylimidazol-1-ium iodide

Alternate Names: LXY-05-029

Molecular Formula: C₂₇H₄₃Cl₂IN₂

Formula Weight: 593.0

CAS Number: 2904601-67-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 100 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Aldolase inhibitor

Functions

Inhibits (IC₅₀ = 50 µM) aldolase by blocking its binding with fructose-1,6-bisphosphate (FBP). It activates lysosomal AMPK and mimics a cellular state of glucose starvation. Aldometanib alleviated fatty liver and nonalcoholic steatohepatitis in mice and extended lifespan. It mitigated inflammation and oxidative stress damage in LPS-treated lung fibroblasts and also inhibited NLRP3-mediated pyroptosis. Inhibited hepatocellular carcinoma in mice in an AMPK-dependent manner. It rebalanced the tumor microenvironment allowing cytotoxic CD8+ T cells to infiltrate tumor cells.

Application Procedures

First dissolved in DMSO (up to at least 100 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4445_Aldometanib_Datasheet

MSDS:

TBI4445_Aldometanib_MSDS

Research use only.