Parthenolide, IκB Kinase inhibitor (TBI2096)

Description

Product Details

Formal Name: Sesquiterpene lactone found in feverfew (Tanacetum parthenium)

Molecular Formula: C₁₅H₂₀O₃

Formula Weight: 248.30

CAS Number: 20554-84-1

Purity: >97%

Formulation: powder

Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

IκB Kinase inhibitor

 

Functions

Parthenolide is a natural product that inhibits NF-κB signaling via two mechanisms: direct inhibition of IκB kinase, and prevention of NOD2 dimerization. It inhibited expression of COX-2 and proinflammatory cytokines TNF alpha and IL-1 in lipopolysaccharide (LPS)-stimulated macrophages. Parthenolide demonstrates antisecretory and spasmolytic activities in vivo. It also causes proteasomal degradation of HDAC1 (but not other class I/II HDACs), and cell death through the ATM pathway.

 

Application Procedures

First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Additional information

SIZE (mg)	250 MG, 50 MG

TBI2096_Parthenolide