GSK2830371, WIP1 phosphatase inhibitor (TBI4180)
$126.00 – $459.00
WIP1 phosphatase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4180-5MG | Yes | 5 MG | $126.00 | |||
TBI4180-25MG | Yes | 25 MG | $459.00 |
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Description
Product Details
Formal Name: 5-[[(5-Chloro-2-methylpyridin-3-yl)amino]methyl]-N-[(2S)-3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl]thiophene-2-carboxamide
Molecular Formula: C23H29ClN4O2S
Formula Weight: 461.00
CAS Number: 1404456-53-6
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
WIP1 phosphatase inhibitor
Functions
Potent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response. It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma, acute myeloid leukemia, and breast. It enhances phosphorylation of the tumor suppressor p53 leading to activation.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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