ANA-12, TrkB antagonist (TBI2828)
$135.00 – $396.00
TrkB antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2828-5MG | Yes | 5 MG | $135.00 | |||
TBI2828-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
Alternate Names: Etacrynic acid
Molecular Formula: C22H21N3O3S
Formula Weight: 407.49
CAS Number: 219766-25-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
TrkB antagonist
Functions
TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively. Systemic administration to adult mice decreased TrkB activity in the brain without affecting neuronal survival or altering TrkA and TrkC functions. Displays antidepressant and anxiolytic properties in mouse models after systemic administration. Shows antidepressant effects on LPS-induced depression-like behavior in mice. Has been used to elucidate the role of BDNF in improvement of cognitive decline during calorie restriction and in the discovery of new neurotrophic agents.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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