ß-Lapachone, Topoisomerase I inhibitor (TBI2386)
$94.00 – $360.00
Topoisomerase I inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2386-5MG | Yes | 5 MG | $94.00 | |||
TBI2386-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Alternate Names: NSC 26326
Molecular Formula: C15H14O3
Formula Weight: 242.27
CAS Number: 4707-32-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Topoisomerase I inhibitor
Functions
A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action. Induces apoptosis in a number of cancer cell lines. In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of β-lapachone leads to futile cycling between quinone and hydroquinone forms resulting in the production of reactive oxygen species. Suppresses radiation-induced activation of NFκB.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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