GW788388, TGFβ receptor inhibitor (TBI5521)
$144.00 – $468.00
TGFβ receptor inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5521-5MG | Yes | 5 MG | $144.00 | |||
TBI5521-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: 4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
Molecular Formula: C25H23N5O2
Formula Weight: 425.50
CAS Number: 452342-67-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (40 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
TGFβ receptor inhibitor
Functions
Potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kinase. Blocks TGF-β-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mouse models. GW788388 attenuates TGF-β-induced epithelial to mesenchymal transition (EMT) in human peritoneal mesothelial cells.
Application Procedures
First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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