Saracatinib, Src family kinase inhibitor (TBI2901)
$72.00 – $261.00
Src family kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2901-5MG | Yes | 5 MG | $72.00 | |||
TBI2901-25MG | Yes | 25 MG | $261.00 |
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Description
Product Details
Formal Name: N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Alternate Names: AZD0530
Molecular Formula: C27H32ClO5N5
Formula Weight: 542.00
CAS Number: 379231-04-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or Ethanol (up to 54 mg/ml, warm).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Src family kinase inhibitor
Functions
Potent and selective inhibitor of Src family kinases, IC50=4-10 nM for Src, c-Yes, Fyn, Lyn, Blk, Fgr and Lck. Demonstrates potent antimigratory, anti-invasive and antiproliferative activity and inhibits metastasis in a mouse model of bladder cancer. Inhibits MERS-CoV at early stages of the viral life cycle at mM concentrations. Rescues memory performance and reduces phospho-Tau accumulation in traumatic tauopathy. Rescues memory deficits and synaptic depletion in an Alzheimer’s mouse model.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or Ethanol (up to 54 mg/ml, warm), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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