AK-7, SIRT2 inhibitor (TBI1429)

Description

Product Details

Formal Name: 3-(1-Azepanylsulfonyl)-N-(3-bromophenyl)benzamide

Molecular Formula: C₁₉H₂₁BrN₂O₃S

Formula Weight: 437.36

CAS Number: 420831-40-9

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).

Storage: RT

Stability: ≥ 2 years.

 

Applications

• SIRT2 inhibitor

 

Functions

AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC₅₀=15.5 μM) which does not inhibit Sirt1 or Sirt3. It down regulates cholesterol biosynthesis genes in primary striatal neurons. AK-7 displays neuroprotective effects in Huntington’s disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin.

Additional information

SIZE (mg)	25 MG, 5 MG

Datasheet:

TBI1429-AK-7

MSDS:

TBI1429_AK-7_MSDS_2024