Splitomicin, SIRT1 inhibitor (TBI2615)
$99.00 – $396.00
SIRT1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2615-5MG | Yes | 5 MG | $99.00 | |||
TBI2615-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Alternate Names: Splitomycin
Molecular Formula: C13H10O2
Formula Weight: 198.22
CAS Number: 5690-03-9
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
- SIRT1 inhibitor
Functions
Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA. Splitomycin inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome. Reverses ischemic preconditioning-induced cardioprotection in a mouse model.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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