SRT1720 HCl, SIRT1 activator (TBI4628)
$135.00 – $585.00
SIRT1 activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4628-5MG | Yes | 5 MG | $135.00 | |||
TBI4628-25MG | Yes | 25 MG | $585.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride
Alternate Names: SIRT 1933
Molecular Formula: C25H23N7OS·HCl
Formula Weight: 506.00
CAS Number: 1001645-58-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
SIRT1 activator
Functions
Sirtuin1 (SIRT1) activator, EC1.5 = 0.16 µM, that reduces glucose levels and hyperinsulinemia in mouse and rat models of obesity. SRT1720 represses expression of circadian clock genes in vitro and in vivo. It inhibits vascular inflammation caused by angiotensin II-induced atherosclerosis and reverses abnormal mitochondrial function in primary neurons exposed to 20-HETE. Ameliorates hypoxic injury in pancreatic β-cells, and enhances ferroptosis in head and neck cancer cells.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “SRT1720 HCl, SIRT1 activator (TBI4628)”
You must be logged in to post a review.
Reviews
There are no reviews yet.