Pridopidine, Sigma-1 Ligand/Neuroprotective/restorative (TBI4003)
$144.00 – $585.00
Sigma-1 Ligand/Neuroprotective/restorative
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4003-5MG | Yes | 5 MG | $144.00 | |||
TBI4003-25MG | Yes | 25 MG | $585.00 |
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Description
Product Details
Formal Name: 4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine
Alternate Names: ACR16
Molecular Formula: C15H23NO2S
Formula Weight: 281.41
CAS Number: 346688-38-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (>25 mg/mL)
Storage: RT
Stability: ≥ 1 year.
Applications
Sigma-1 Ligand/Neuroprotective/restorative
Functions
Pridopidine is being studied as a potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects. It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”). More recent studies have attributed pridopidine’s effects to its being a more potent sigma-1 ligand than a D2 ligand. Displays neuroprotective/restorative effects and ameliorates central features of amyotrophic lateral sclerosis pathology in a sigma-1-mediated manner
Application Procedures
First dissolved in DMSO (>25 mg/mL), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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