Canagliflozin, SGLT2 inhibitor (TBI3576)
$90.00 – $288.00
SGLT2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3576-5MG | Yes | 5 MG | $90.00 | |||
TBI3576-25MG | Yes | 25 MG | $288.00 |
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Description
Product Details
Formal Name: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol
Alternate Names: JNJ-24831754
Molecular Formula: C24H25FO5S
Formula Weight: 444.50
CAS Number: 842133-18-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
SGLT2 inhibitor
Functions
Potent inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), IC50 = 2.2 nM selective over SGLT1, IC50=910 nM. Dose dependently increases glucose excretion in healthy subjects. Displays beneficial effects in nonalcoholic fatty liver disease (NAFLD). Extends lifespan in male but not female mice. Inhibits cancer cell proliferation via inhibition of mitochondrial complex-1 supported respiration. Suppresses the growth of pancreatic cancer cells.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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