ABT-737, Senolytic Bcl2 inhibitor (TBI3661)
$144.00 – $441.00
Senolytic Bcl2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3661-5MG | Yes | 5 MG | $144.00 | |||
TBI3661-25MG | Yes | 25 MG | $441.00 |
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Description
Product Details
Formal Name: 4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide
Molecular Formula: C42H45ClN6O5S2
Formula Weight: 813.40
CAS Number: 852808-04-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Senolytic Bcl2 inhibitor
Functions
Inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regression of solid tumors in mice. Senolytic agent which disrupts aberrant p21 expression, inducing apoptosis in senescent cells, and enhancing liver regeneration in mice. Acts synergistically to reduce cell viability when combined with CDK inhibitor purvalanol A in preclinical models of acute myeloid leukemia (AML).
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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