S1RA, Selective sigma-1 antagonist (TBI4201)
$153.00 – $540.00
Selective sigma-1 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4201-5MG | Yes | 5 MG | $153.00 | |||
TBI4201-25MG | Yes | 25 MG | $540.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 4-{2-[5-Methyl-1-(napthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine hydrochloride
Alternate Names: E-52862 HCl
Molecular Formula: C20H23N3O2·HCl
Formula Weight: 373.88
CAS Number: 1265917-14-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective sigma-1 antagonist
Functions
S1RA (E-52862) is a potent and selective σ1 antagonist with weak binding at σ2 (IC50’s: σ1 = 17nM, σ2 = 9300nM). S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner. BD1063 potentiated µ-opioid antinociception in mice in a σ-dependent manner. S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “S1RA, Selective sigma-1 antagonist (TBI4201)”
You must be logged in to post a review.
Reviews
There are no reviews yet.