Quizartinib, Selective FLT3 inhibitor (TBI4813)
$90.00 – $234.00
Selective FLT3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4813-5MG | Yes | 5 MG | $90.00 | |||
TBI4813-25MG | Yes | 25 MG | $234.00 |
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Description
Product Details
Formal Name: 1-(5-(t-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea
Alternate Names: AC220
Molecular Formula: C29H32N6O4S
Formula Weight: 560.67
CAS Number: 950769-58-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective FLT3 inhibitor
Functions
Quizartinib is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells). It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML). Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine. Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance (@ 3 µM) via antagonism of drug efflux function.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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