SC-560, Selective COX-1 inhibitor (TBI2531)
$90.00 – $351.00
Selective COX-1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2531-5MG | Yes | 5 MG | $90.00 | |||
TBI2531-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Molecular Formula: C17H12ClF3N2O
Formula Weight: 352.70
CAS Number: 188817-13-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective COX-1 inhibitor
Functions
SC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1). SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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