Locostatin, RKIP / Raf-1 kinase disruptor (TBI5381)
$86.00 – $243.00
RIPK1 inhibitor; Necroptosis inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5381-5MG | Yes | 5 MG | $86.00 | |||
TBI5381-25MG | Yes | 25 MG | $243.00 |
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Description
Product Details
Formal Name: (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone
Alternate Names: UIC-1005
Molecular Formula: C14H15NO3
Formula Weight: 245.30
CAS Number: 133812-16-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (60 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
RKIP / Raf-1 kinase disruptor
Functions
Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase. Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2. Effectively inhibits cytokine release by human lymphocytes. Alleviates CCl4-induced liver liver fibrosis in a mouse model. A useful probe to explore the complex functions of RKIP in cell physiology.
Application Procedures
First dissolved in DMSO (60 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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