DJ001, PTPσ inhibitor (TBI3800)
$126.00 – $540.00
Protein tyrosine phosphatase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3800-5MG | Yes | 5 MG | $126.00 | |||
TBI3800-25MG | Yes | 25 MG | $540.00 |
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Description
Product Details
Formal Name: (Z)-3-((3-Nitrophenyl)amino)-1-phenylprop-2-en-1-one
Molecular Formula: C15H12N2O3
Formula Weight: 268.30
CAS Number: 2161305-12-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO up to 50 mg/ml, or Ethanol (10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
PTPσ inhibitor
Functions
Potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTPσ) IC50=1.54 µM and >10 µM for 20 other phosphatases. Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouracil or radiation, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTPs is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.
Application Procedures
First dissolved in DMSO up to 50 mg/ml, or Ethanol (10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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