Crenolanib, PDGFR and FLT3 inhibitor (TBI4782)
$108.00 – $351.00
PDGFR and FLT3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4782-5MG | Yes | 5 MG | $108.00 | |||
TBI4782-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine
Alternate Names: CP-868,596
Molecular Formula: C26H29N5O2
Formula Weight: 443.55
CAS Number: 670220-88-9
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PDGFR and FLT3 inhibitor
Functions
Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ß = 3.2 nM) and FLT3 (Kd = 0.74 nM). Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I843 as well as FLT3/ITD and FLT3/D835 mutants. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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