Ponatinib, Pan-Bcr-Abl and multikinase inhibitor (TBI5064)
$90.00 – $306.00
Pan-Bcr-Abl and multikinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI5064-5MG | Yes | 5 MG | $90.00 | |||
TBI5064-25MG | Yes | 25 MG | $306.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
Alternate Names: AP-24534
Molecular Formula: C29H27F3N6O
Formula Weight: 532.56
CAS Number: 943319-70-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 50 mg/ml); or Ethanol (25 mg/ml, warm)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Pan-Bcr-Abl and multikinase inhibitor
Functions
Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM). Also inhibits PDGFRα, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively) as well as FGFR-mediated signaling (IC50<40 nM). Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.
Application Procedures
First dissolved in DMSO (up to at least 50 mg/ml); or Ethanol (25 mg/ml, warm), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “Ponatinib, Pan-Bcr-Abl and multikinase inhibitor (TBI5064)”
You must be logged in to post a review.
Reviews
There are no reviews yet.