A-438079, P2X7 antagonist (TBI4063)
$108.00 – $405.00
P2X7 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4063-5MG | Yes | 5 MG | $108.00 | |||
TBI4063-25MG | Yes | 25 MG | $405.00 |
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Description
Product Details
Formal Name: 3-[5-(2,3-Dichlorophenyl)tetrazol-1-ylmethyl]pyridine hydrochloride
Molecular Formula: C13H9Cl2N5·HCl
Formula Weight: 342.61
CAS Number: 899431-18-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
P2X7 antagonist
Functions
Competitive P2X7 receptor antagonist (pIC50 = 6.9). Displayed antinociceptive effects in a rat model of neuropathic pain. A-438079 prevented the LPS-induced release of IL-1ß and attenuated LPS-induced (via intrathecal lumbar injection) mechanical hyperalgesia in rat hindpaws. It prevented mechanical hyperalgesia following peripheral nerve injury. A-438079 protected against cerebral ischemia/reperfusion injury in a rat model via reduction of the neuroinflammatory response.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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