Thiamet-G, O-GlcNAcase alpha 1 antagonist (TBI2824)
$126.00 – $468.00
O-GlcNAcase alpha 1 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2824-5MG | Yes | 5 MG | $126.00 | |||
TBI2824-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol
Alternate Names: Thiamet G
Molecular Formula: C9H16N2O4S
Formula Weight: 248.30
CAS Number: 1009816-48-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
O-GlcNAcase alpha 1 antagonist
Functions
Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus. Stabilizes tau against aggregation and slows neurodegeneration. Prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice. Active in vivo and blood brain barrier permeable.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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