FLI-06, Notch pathway inhibitor (TBI1504)
$117.00 – $468.00
Notch pathway inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1504-5MG | Yes | 5 MG | $117.00 | |||
TBI1504-25MG | Yes | 25 MG | $468.00 |
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Description
Product Details
Formal Name: Cyclohexyl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Molecular Formula: C25H30N2O5
Formula Weight: 438.52
CAS Number: 313967-18-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Notch pathway inhibitor
Functions
FLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 μM). Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma. Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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