PF-05089771, Nav1.7 inhibitor (selective) (TBI3990)
$108.00 – $432.00
Nav1.7 inhibitor (selective)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3990-5MG | Yes | 5 MG | $108.00 | |||
TBI3990-25MG | Yes | 25 MG | $432.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide
Alternate Names: PF771
Molecular Formula: C18H12Cl2FN5O3S2
Formula Weight: 500.34
CAS Number: 1235403-62-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Nav1.7 inhibitor (selective)
Functions
Potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7). It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 µM for resting channels. Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “PF-05089771, Nav1.7 inhibitor (selective) (TBI3990)”
You must be logged in to post a review.
Reviews
There are no reviews yet.