Pazopanib, Multi-receptor tyrosine kinase inhibitor (TBI2158)
$72.00 – $216.00
Multi-receptor tyrosine kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2158-5MG | Yes | 5 MG | $72.00 | |||
TBI2158-25MG | Yes | 25 MG | $216.00 |
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Description
Product Details
Formal Name: 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide
Alternate Names: GSK-VEG10003; GW786034B
Molecular Formula: C21H23N7O2S
Formula Weight: 437.50
CAS Number: 444731-52-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 16 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Multi-receptor tyrosine kinase inhibitor
Functions
Inhibits multiple receptor tyrosine kinases including VEGFR1,2 and 3 (IC50s=10, 30, 47 nM respectively) and PDGFRα, β and c-Kit (IC50s=71, 84, 74 nM respectively) and others such as FGFR. The drug targets both the tumor and endothelial cells in a mouse xenograft model of human multiple myeloma. It reduces joint pain and inhibits cartilage degeneration in rodent osteoarthritis models. VEGF inhibitors such as pazopanib have potential for treatment of neovascular age-related macular degeneration. In clinical use for renal cell carcinoma.
Application Procedures
First dissolved in DMSO (up to 16 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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