SGC-iMLLT, MLLT1/3 YEATS domain inhibitor (TBI4046)
$135.00 – $513.00
MLLT1/3 YEATS domain inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4046-5MG | Yes | 5 MG | $135.00 | |||
TBI4046-25MG | Yes | 25 MG | $513.00 |
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Description
Product Details
Formal Name: (S)-1-Methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazole-5-yl)-1H-indazole-5-carboxamide
Molecular Formula: C22H24N6O
Formula Weight: 388.50
CAS Number: 2255338-25-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
MLLT1/3 YEATS domain inhibitor
Functions
Potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3. YEATS domain containing proteins bind acetyl and crotonyl marks on histone tails. Selective against the two other human YEATS domains YEATS2/4 and 48 bromodomains. YEATS containing MLL-ENL leukemic cells display increased sensitivity to SGC-iMLLT versus control AML cells.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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