URMC-099, MLK3 inhibitor (TBI4012)
$99.00 – $342.00
MLK3 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4012-5MG | Yes | 5 MG | $99.00 | |||
TBI4012-25MG | Yes | 25 MG | $342.00 |
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Description
Product Details
Formal Name: 3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine
Molecular Formula: C27H27N5
Formula Weight: 421.50
CAS Number: 1229582-33-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
MLK3 inhibitor
Functions
URMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM). URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders and facilitated microglial amyloid-β degradation and clearance in mouse models. URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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