TIC10, Mitochondrial caseinolytic protease P activator / Anticancer agent (TBI4090)
$90.00 – $351.00
Mitochondrial caseinolytic protease P activator / Anticancer agent
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI4090-5MG | Yes | 5 MG | $90.00 | |||
| TBI4090-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
Alternate Names: ONC201
Molecular Formula: C24H26N4O
Formula Weight: 386.49
CAS Number: 1616632-77-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Mitochondrial caseinolytic protease P activator / Anticancer agent
Functions
Novel anti-cancer compound that activates early-stage integrated stress response, causing selective cancer cell death. Potently activates mitochondrial caseinolytic protease P (ClpP), resulting in eIF2α-independent induction of ATF4 and Akt/ERK/Foxo3a/DR5/TRAIL-dependent apoptosis. Currently in clinical trials.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
| SIZE (mg) | 25 MG, 5 MG |
|---|
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