Mito-lonidamine, Mitochondria-targeted antiglycolytic agent (TBI5492)
$180.00 – $720.00
Mitochondria-targeted antiglycolytic agent
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5492-5MG | Yes | 5 MG | $180.00 | |||
TBI5492-25MG | Yes | 25 MG | $720.00 |
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Description
Product Details
Formal Name: (10-(1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxamido)decyl)triphenylphosphonium bromide
Molecular Formula: C43H45BrCl2N3OP
Formula Weight: 801.60
CAS Number: 2361564-49-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Mitochondria-targeted antiglycolytic agent
Functions
Lonidamine is an antiglycolytic drug with limited efficacy. Mito-lonidamine is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group. Mito-lonidamine was shown to be100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.
Application Procedures
First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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