BAM15, Mitochondrial oxidative phosphorylation inhibitor (TBI5104)
$108.00 – $441.00
Mitochondrial oxidative phosphorylation inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5104-5MG | Yes | 5 MG | $108.00 | |||
TBI5104-25MG | Yes | 25 MG | $441.00 |
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Description
Product Details
Formal Name: N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Molecular Formula: C16H10F2N6O
Formula Weight: 340.30
CAS Number: 210302-17-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 35 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Mitochondrial oxidative phosphorylation inhibitor
Functions
A mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria). Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum rate of mitochondrial respiration and does not depolarize the plasma membrane. Stimulates energy expenditure, protects against obesity and improves glycemic control in rodent models. Reverses diet-induced obesity and insulin resistance in mice. Attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
Application Procedures
First dissolved in DMSO (up to at least 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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