PF-9366, Methionine adenosyltransferase 2A inhibitor (TBI4635)
$108.00 – $441.00
Methionine adenosyltransferase 2A inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4635-5MG | Yes | 5 MG | $108.00 | |||
TBI4635-25MG | Yes | 25 MG | $441.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 2-(7-Chloro-5-phenyl)-[1,2,4]triazolo[4,3-a]quinoline-1-yl)-N,N,dimethylethanamine
Molecular Formula: C20H19ClN4
Formula Weight: 350.85
CAS Number: 72882-78-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Methionine adenosyltransferase 2A inhibitor
Functions
PF-9366 is an allosteric inhibitor (IC50 = 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM). It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 µM and 225 nM respectively.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “PF-9366, Methionine adenosyltransferase 2A inhibitor (TBI4635)”
You must be logged in to post a review.
Reviews
There are no reviews yet.