CZC-54252, LRRK2 inhibitor (TBI1421)
$153.00 – $612.00
LRRK2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1421-5MG | Yes | 5 MG | $153.00 | |||
TBI1421-25MG | Yes | 25 MG | $612.00 |
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Description
Product Details
Formal Name: N-[[[5-Chloro-2-[[2-methoxy-4-(4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-phenyl]methanesulfonamide hydrochloride
Molecular Formula: C22H25ClN6O4S · HCl
Formula Weight: 541.46
CAS Number: 1199911-27-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
LRRK2 inhibitor
Functions
Novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM. Attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM)1. The G2019S mutant is a common mutation found in familial Parkinson’s disease patients. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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