4µ8C, IRE1 ribonuclease inhibitor (TBI1579)
$58.00 – $180.00
IRE1 ribonuclease inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1579-5MG | Yes | 5 MG | $58.00 | |||
TBI1579-25MG | Yes | 25 MG | $180.00 |
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Description
Product Details
Formal Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Molecular Formula: C11H8O4
Formula Weight: 204.18
CAS Number: 14003-96-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
IRE1 ribonuclease inhibitor
Functions
Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells. Blocks production of IL-4, IL-5 and IL-13 production in T cells. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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